Name: Epithalon
Brand: Hati Peptides
SKU: EPI-10MG
Price: 17.95 GBP
Availability: OutOfStock

Question 1

What is Epithalon and how does it work in research models?

Accepted Answer

Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) with a molecular weight of ~390.4 Da. Originally isolated from the pineal gland, it is studied in cellular models for its effects on telomerase activity, cellular senescence, and pineal-axis function. The peptide upregulates telomerase expression and activity in fibroblast and epithelial cell cultures, potentially extending replicative lifespan. It also modulates melatonin synthesis enzymes and circadian rhythm gene expression in pineal cell cultures.

Question 2

How do I reconstitute Epithalon for laboratory use?

Accepted Answer

Reconstitute lyophilised Epithalon with bacteriostatic water (0.9% benzyl alcohol). Inject the water slowly down the inside wall of the vial. The small peptide readily dissolves with minimal mixing. Typical research stock concentrations range from 1–10 mg/mL. Store lyophilised powder at −20°C; reconstituted solution at 2–8°C, protected from light. Solutions are stable for 7–14 days under refrigeration. The peptide is relatively stable but should be protected from extremes of pH and temperature.

Question 3

What purity standard is recommended for Epithalon research?

Accepted Answer

Research-grade Epithalon should be ≥98% pure by HPLC, with ≥99% being the preferred standard. Mass spectrometry identity confirmation is essential to verify the 4-amino-acid sequence (Ala-Glu-Asp-Gly) and molecular weight (~390.4 Da). Given the peptide's small size, sequence verification is critical. Batch-specific Certificates of Analysis should document purity, identity, and endotoxin levels. The peptide is highly susceptible to synthesis errors due to its short length, making analytical verification particularly important.

Question 4

Is Epithalon legal for research in the UK?

Accepted Answer

Yes. Epithalon is not a controlled substance under the UK Misuse of Drugs Act 1971 and is not scheduled under the Psychoactive Substances Act 2016. It is classified as a research peptide for laboratory use and is not licensed as a medicine by the MHRA. Research institutions should ensure compliance with institutional ethics approvals and standard laboratory safety protocols.

Question 5

What cellular models are used for Epithalon research?

Accepted Answer

Standard cellular models include: (1) primary human fibroblast cultures for lifespan and senescence studies; (2) telomerase activity assays using TRAP protocol; (3) pinealocyte cultures for melatonin synthesis studies; (4) DNA repair assays using comet assay and γ-H2AX foci; (5) stem cell cultures for proliferation and differentiation studies; and (6) epithelial cell cultures for telomere length maintenance studies. Researchers compare Epithalon to NAD+ precursors and sirtuin activators in longevity studies.

Epithalon

Epithalon

Research Overview

Areas of Interest

Technical Specifications

Certificate of Analysis